총괄과제 및 제1세부과제 책임연구원: 유영현교수 (Young Hyun Yoo, Professor)
1983. 02 부산대학교 의과대학 의학과 졸업
동아대학교 의과대학 해부학교실
1985. 02 부산대학교 대학원 의학과 석사 학위취득
1989. 02 부산대학교 대학원 의학과 박사 학위취득
1994 - 1996 University of Pennsylvania, Visiting Professor
Apoptosis related diseases
Im E, Choi S-H, Suh H, Choi YH, Yoo YH, Kim ND. Synthetic bile acid derivatives induce apoptosis through a c-Jun N-terminal kinase and NF-kappaB-dependent process in human cervical carcinoma cells. Cancer Lett (in press)
Lee SW, Chung WT, Choi SM, Kim KT, Yoo YH. SKI 306X protected to apoptosis of rat chondrocytes. J Ethnopharmacol (in press)
Rho JH, Kang D-Y, Park KJ, Choi HJ, Yee S-B, Yoo YH. Doxorubicin induces apoptosis with profile of large-scale DNA fragmentation and without DNA ladder in anaplastic thyroid carcinoma cells via histone hyperacetylation. Int J Oncol (in press)
Park YC, Jeong JH, Park KJ, Choi HJ, Park YM, Jeong BK, Higuchi Y, Yoo YH. Sulindac activates nuclear translocation of DFF40 and Endo G but not induces oligonucleosomal DNA fragmentation in HT-29 cells. Life Sci (in press)
Park BS, Song YS, Yee S-B, Lee BG, Seo SY, Park YC, Kim J-M, Kim HM, and Yoo YH. Phospho-Ser 15-p53 Translocates into Mitochondria and Interacts with Bcl-2 and Bcl-xL in Eugenol-Induced apoptosis. Apoptosis 10: 193-200, 2005; Apoptosis
SU-BOG YEE, MYUNG SOO KIM, SOO JIN BAEK, GYOO CHEON KIM, KI SOO YOO, YOUNG HYUN YOO and BONG SOO PARK. Trichostatin Ainduces apoptosis of p815 mastocytoma cells in histone acetylation- and mitochondria-dependent fashions. Int J Oncol 25(5):1431-1436, 2004
Roh MS, KIM CW, Park BS, Kim GC, Jeong JH, Kwon HC, Suh DJ, Cho KH, Yee S-B, Yoo YH. Mechanism of histone deaceylase inhibior trichostatin A induced apoptosis in human osteosarcoma cells. Apoptosis 9:583-589, 2004
(S, 2.536) Park SE, Choi HJ, Yee S-B, Chung HY, Suh H, Choi YH, Yoo YH, Kim ND. Synthetic bile acid derivatives inhibit cell proliferation and induce apoptosis in HT-29 human colon cancer cells. Int J Oncol 25(1): 231-236, 2004.
Park SE, Kim ND, Yoo YH. Acetylcholinesterase plays a pivotal role in apoptosome formation. Cancer Res 64:2652-2655, 2004
Yi JM, Kim MS, Koo HN, Song BK, Yoo YH, Kim HM. Poncirus trifoliata fruit induces apoptosis in human promyelocytic leukemia cells. Clin Chim Acta 340(1-2): 179-85, 2004.
Koo HN, Hong SH, Song BK, Kim CH, Yoo YH, Kim HM. Taraxacum officinale induces cytotoxicity through TNF-alpha and IL-1alpha secretion in Hep G2 cells. Life Sci 74(9):1149-1157, 2004
Sung Won Lee, Hye Jeong Lee, Won Tae Chung, Sun Mee Choi, Seung Hoon Rhyu, Duk Kyu Kim, Kyung Taek Kim, Ji Young Kim, Jong-Min Kim, Young Hyun Yoo. TRAIL induces apoptosis of chondrocyte and influences the pathogenesis of experimentally induced rat osteoarthritis. Arthritis and Rheumatism 50(2):534-542, 2004
Jin Hee Jeong, Joo-Sung Park, Bongkyung Moon, Min Chan Kim, Jae-Kon Kim, Sungeun Lee, Hongsuk Suh, Nam Deuk Kim, Jong-Min Kim, Young Chul Park, Young Hyun Yoo. An orphan nuclear receptor Nur77 translocates to mitochondria in the early phase of synthetic chenodeoxycholic acid derivatives-induced apoptosis of human stomach cancer cell line SNU-122. 2003 Ann New York Acad Sci 110:171-177, 2003
Yoo YH, Lim YJ, Park SE, Kim J, Park YC, Overexpression of redox factor-1 negatively regulates NO synthesis and apoptosis in LPS-stimulated RAW 264.7 macrophages. FEBS Lett 556(1-3):39-42, 2004.
Choi YH, Im EO, Suh H, Jin Y, Yoo YH, Kim ND, Apoptosis and modulation of cell cycle control by synthetic derivatives of ursodeoxycholic acid and chenodeoxycholic acid in human prostate cancer cells. Cancer Lett 199(2):157-167, 2003.
Kim GC, Lee SG, Park BS, Kim JY, Song YS, Kim J, Yoo KS, Huh GY, Jeong MH, Lim YJ, Kim HM, Yoo YH, Magnoliae flos induces apoptosis of RBL-2H3 cells via mitochondria and caspase. Int Arch Allergy Immunol 131(2):101-110, 2003.
Seo SY, Jun EJ, Jung SM, Kim K-H, Lim YJ, Park BS, Kim J, Lee S, Suh H, Kim ND, Yoo YH, A synthetic CDCA derivative HS-1200-induced apoptosis of p815 mastocytoma cells is augmented by co-treatment with lactacystin. Anticancer Drugs 14(3):219-225, 2003.
Choi HJ, Kim HH, Lee HS, Huh GY, Seo SY, Jeong JH, Kim JM, Yoo YH, Lactacystin augments the sulindac-induced apoptosis in HT-29 cells. Apoptosis 8(3):301-305, 2003.
Kim JM, Bae HR, Park BS, Lee JM, Ahn HB, Rho JH, Yoo KW, Park WC, Rho SH, Yoon HS, Yoo YH, Early mitochondrial hyperpolarization and intracellular alkalinization in Lactacystin induced apoptosis of retinal pigment epithelial cells. JPET 305(2):474-481, 2003.
Yoon S, Yoo HJ, Shim NR, Baek SY, Kim BS, Kim JB, Jun EJ, Son YK, Lee SY, Yoo YH, Immunohistochemical Characterization of Macrophage and Dendritic Cell Subpopulations of the Spleen, Thymus, Tongue and Heart in Cyclophosphamide-induced Immunosuppressed Rat. Anat Histol Embryol 32(2):80-88, 2003.
Park BS, Baek SJ, Song KH, Kim GH, Jeong SJ, Jeong MH, Seo SY, Lee SW, Yoo KS, Yoo YH. Genistein-induced apoptosis of p815 mastocytoma cells is mediated by Bax and augmented by a proteasome inhibitor lactacystin. Nutrtion and Cancer 42(2):248-255, 2002.
Park SJ, Cho SS, Oh JM, Han MK, Song YS, Bae HR, Yoo YH, Kim HM, Promoted expression of mast cell-specific proteases in IgE-dependent passive cutaneous anaphylaxis responses. Clinica Chimica Acta 314(1-2):231-236, 2001.
Jeong SJ, Jin YH, Moon CW, Bae HR, Yoo YH, Lee HS, Lee SH, Lim YJ, Lee JD, Jeong MH, PTK inhibitors modulate the radiosensitivity and radiation-induced apoptosis following ionizing radiation of K562 cells. Rad Res 156(6):751-760, 2001.
Roh SH, Yoon HS, Yoo KW, Park WC, Jeong JH, Yoo YH, Antisense bFGF oligonucleotide reduced adhesion of RPE cells to extracellular matrix molecules and their proliferation. Ophthalmic Research 33(1):24-30, 2001.
Choi YH, Im EO, Suh H, Jin Y, Lee WH, Yoo YH, Kim KW, Kim ND,Apoptotic activity of novel bile acid derivatives in human leukemic T cells through the activation of caspases. Int J Oncol 18(5):979-984, 2001.
Park HI, Jeong MH, Lim YJ, Park BS, Kim GC, Kim HM, Yoo KS, Yoo YH, Syzygium aromaticum (L.) Merr. Et Perry (Myrtaceae) flower bud Induces apoptosis of p815 mastocytoma cell line. Life Sci 69(5):553-566, 2001.
Yoon HS, Rho JH, Yoo KW, Park WC, Rho SH, Choi YH, Suh H, Kim ND, Yoo KS, Yoo YH, Synthetic bile acid derivatives induce nonapoptotic death of human retinal pigment epithelial cells. Curr Eye Res 22(5):367-374, 2001.
Im E, Choi YH, Suh H, Jin Y, Kim KW, Yoo YH, Kim ND, Novel bile acid derivatives induced apoptosis by p53-independent pathway in human breast carcinoma cells. Cancer Letters 163(1):83-93, 2001.
Yoon HS, Moon SC, Kim ND, Park BS, Jeong M, Yoo YH: Genistein induces apoptosis of RPE-J cells by opening mitochondrial PTP. BBRC 276(1):151-156, 2000
Jeong MH, Jeong SJ, Jo WS, Yu SH, Lee SH, Yee ST, Yoo YH, Kim JM, LIM YJ: A Novel Factor isolated from Actinobacillus actinomycetemcomitans Stimulates Mouse B Cells and Human Peripheral Blood Mononuclear Cells. Inf Imm 68(9):5132-5138, 2000
Park BS, Kim GC, Baek SJ, Kim ND, Kim YS, Kim SK, Jeong MH, Lim YJ, Yoo YH: Murine Bone Marrow-Derived Mast cells Exhibit Evidence of Both Apoptosis and Oncosis after IL-3 Deprivation. Immunol Invest 29(1):51-60, 2000
Yoon HS, Roh SH, Jeong JH, Yoon S, Yoo KS, Yoo YH: Genistein produces reduction in growth and induces apoptosis of rat RPE-J cells. Curr Eye Res 20(3):215-224, 2000
제2세부과제 책임연구원: 박환태교수
1990. 02 부산대학교 의과대학 의학과 졸업
동아대학교 의과대학 생리학교실
1994. 02 부산대학교 대학원 의학과 박사 학위취득
1997-2003 인제대학교 의과대학 해부학교실 전임강사 및 조교수
2000 - 2002 Postdoctoral Fellowship
Washington University Medical School
Department of Anatomy and Neurobiology
Dr. Yi Rao Lab: Axon guidance and neuronal migration
Anti-apoptotic role neural guidance molecules during neural development and nerve regeneration
Molecular Mechanism of Spinal cord and nerve regeneration
Lee HK, Bae HR, Park HK, Seo IA, Lee EY, Suh DJ, Park HT. Cloning, characterization and neuronal expression profiles of tumor endothelial marker 7 in the rat brain. Brain Res Mol Brain Res. 2005 May 20;136(1-2):189-98.
Kang DY, Park JI, Cho WS, Jeong MH, Cho GW, Park HT, Bae HR. Identification of vasopressin-induced genes in AQP2-transfected MDCK cells by suppression subtractive hybridization. Biochem Biophys Res Commun. 2004 Nov 26;324(4):1234-41
Liu G, Beggs H, Jurgensen C, Park HT, Tang H, Gorski J, Jones KR, Reichardt LF, Wu J, Rao Y. Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction. Nat Neurosci. 2004 Nov;7(11):1222-32.
Jeong MH, Jin YH, Kang EY, Jo WS, Park HT, Lee JD, Yoo YJ, Jeong SJ. The modulation of radiation-induced cell death by genistein in K562 cells: activation of thymidine kinase 1. Cell Res. 2004 Aug;14(4):295-302
Park HT, Wu J, Rao Y, Molecular control of neuronal migration. Bioessays, 24(9), 821-827, 2002.
Wong K, Park HT, Wu JY, Rao Y. Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. Curr Opin Genet Dev. 12(5), 583-591, 2002.
Wu JY, Feng L, Park HT, Havlioglu N, Wen L, Tang H, Bacon KB, Jiang Zh, Zhang Xc, Rao Y. The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature. 410(6831), 948-952, 2001.
Park JH, Park JK, Bae KW, Park HT. Protein kinase A activity is required for depolarization-induced proline-rich tyrosine kinase 2 and mitogen-activated protein kinase activation in PC12 cells. Neurosci Lett. 290(1):25-28, 2000.
Lee SA, Park JK, Kang EK, Bae HR, Bae KW, Park HT. Calmodulin-dependent activation of p38 and p42/44 mitogen-activated protein kinases contributes to c-fos expression by calcium in PC12 cells: modulation by nitric oxide. Brain Res Mol Brain Res. 2000 Jan 10;75(1):16-24
제3세부과제 책임연구원: 이혜정교수
1989. 02 부산대학교 의과대학 의학과 졸업
동아대학교 의과대학 약리학교실
1992. 02 부산대학교 대학원 의학과 석사 학위취득
1995. 02 연세대학교 대학원 의학과 박사 학위취득
1998 - 1999 Baylor College of Medicine (Houston, Texas) 세포생물학 조교수
바이러스 벡터를 이용한 유전자 치료법 개발
당뇨병의 병리 기전 연구 및 치료제 개발
Hwang JT, Lee M, Jung SN, Lee HJ, Kang I, Kim SS, Ha J. AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. Carcinogenesis. 2004, 25:2497-507
Sung Won Lee, Hye-Jeong Lee, Won Tae Chung, Sun Mi Choi, Ji Young Kim, Jong-Min Kim, Young Hyun Yoo, TRAIL implicates in the pathogenesis of osteoarthritis. Arthritis Rheum. 2004, 50:534-42
Mi-Kyoung Park, Duk-Kyu Kim, Hye-Jeong Lee. Adenoviral mediated hepatocyte growth factor gene attenuates hyperglycemia and beta cell destruction in overt diabetic mice. Exp. Mol. Med. 2003, 35:494-500
Hye-Jeong Lee, Hyun-Jeong Kim, Mee-Sook Roh, Jai-Ik Lee, Sung-Won Lee, Hyuk-Chan Kwon, Dong-Sik Jung, Duk Kyu Kim, Mi Kyoung Park. The Prevention of Diabetes Using Adenoviral Mediated Hepatocyte Growth Factor Gene Transfer in mice. Korean J Physiol Pharmacol 2003, 7:261-266
Lee M, Hwang JT, Lee HJ, Jung SN, Kang I, Chi SG, Kim SS, Ha J. AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells. J Biol Chem. 2003, 278:39653-61.
Hwang TH, Yoon BC, Jeong JS, Seo SY, Lee HJ. A single administration of adenoviral-mediated HGF cDNA permits survival of mice from acute hepatic failure. Life Sci. 2003, 72:851-61.
Lee, H.J., Choi, S.S., Park, M.K., Hwang, T.H., Kim,D.K. Fenofibrate lowers abdominal and skeletal adiposity and improves insulin sensitivity in OLETF rats. Biochem. Biophys. Res. Commun.2002, 296:293-299