1989. 02 부산대학교 분자생물학과 졸업
부산대학교 의과대학 미생물학교실
1991. 02 부산대학교 대학원 미생물학과 석사 학위취득
1996. 02 부산대학교 대학원 분자생물학과 박사 학위취득
1996-1997: Postdoctoral fellow, Department of Microbiology and Immunology, Wonkwang University School of Medicine
1998-2000: Postdoctoral fellow, Department of Molecular & Cell Biology, University of California at Berkeley, USA
2001-2003: Postdoctoral fellow, Division of Cardiology, School of Medicine, Johns Hopkins University, USA
2003-2004: Research Professor, College of Medicine, Dong-A University
Free radical biology in aging & cancer
Mast cell biology
Immune cell receptor signaling
Young Chul Park, Gerald Rimbach, Claude Saliou, Giuseppe Valacchi, and Lester Packer Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF-a secretion, and NF-B-dependent gene expression in RAW 264.7 macrophages. FEBS Lett. 465(2-3): 93-97, 2000
Gerald Rimbach*, Young Chul Park*, Qiong Guo, Hadi Moini, Nilofer Qureshi, Claude Saliou, Kuni Takayama, Fabio Virgili, and Lester Packer Nitric oxide synthesis and TNF-a secretion in RAW 264.7 macrophages: Mode of action of a fermented papaya preparation. Life Sci. 67: 679-694, 2000 (*, co-first authors)
Hadi Moini, Oren Tirosh, Young Chul Park, Kyung-Joo Cho, and Lester Packer R--lipoic acid action on cell redox status, the insulin receptor, and glucose uptake in 3T3-L1 adipocytes. Arch. Biochem. Biophys. 397(2): 384-391, 2002
Piem Angkeow, Shailesh Deshpande, Bing Qi, Yan-Xia Liu, Young Chul Park, Byeong Hwa Jeon, M. Ozaki, and Kaikobad Irani Redox factor-1: An extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis. Cell Death & Differentiation 9(7): 717-725, 2002
Shailesh Deshpande, Bing Qi, Young Chul Park, and Kaikobad Irani Constitutive activation of rac1 regulates mitochondrial oxidative stress and induces premature endothelial cell senescence. Arteriosclerosis, Thrombosis & Vascular Biology 23(1): e1-6, 2003
Jin Hee Jeong, Joo-Sung Park, Bongkyung Moon, Min Chan Kim, Jae-Kon Kim, Sungeun Lee, Hongsuk Suh, Nam Deuk Kim, Young Chul Park, and Young Hyun Yoo Orphan nuclear receptor Nur77 translocates to mitochondria in the early phase of apoptosis induced by synthetic chenodeoxycholic acid derivatives in human stomach cancer cell line SNU-1. Ann N.Y. Acad. Sci. 1010: 171-177, 2003
Young Hyun Yoo, Young Jin Lim, Sang Eun Park, Jong-Min Kim, and Young Chul Park Overexpression of redox factor-1 negatively regulates nitric oxide synthesis and apoptosis in LPS-stimulated RAW 264.7 macrophages. FEBS Lett. 556(1-3): 39-42, 2004
BH Jeon, G Gupta, YC Park, B Qi, A Haile, FA Khanday, YX Liu, JM Kim, M Ozaki, AR White, DE Berkowitz, and K Irani Apurinic/apymidinic endonuclease 1 regulates endothelial NO production and vascular tone. Circ. Res. 95(9): 902-910, 2004
GY Kim, WK Oh, BC Shin, YI Shin, YC Park, SC Ahn, JD Lee, YS Bae, JY Kwak, and YM Park Proteoglycan isolated from Phellinus Linteus inhibits tumor growth through mechanisms leading to an activation of CD11c+CD8+ DC and type I helper T cell-dominant immune state. FEBS Lett. 576(3): 391-400, 2004
BS Park, YS Song, SB Yee, BG Lee, SY Seo, YC Park, JM Kim, HM Kim, and YH Yoo Phospho-ser 5-p53 translocates into mitochondria and interacts with Bcl-2 and Bcl-xl in eugenol-induced apoptosis. Apoptosis 10: 193-200, 2005
동아대학교 의과대학 미생물학교실
1983. 02 부산대학교 의과대학 의학과 졸업
1985. 02 부산대학교 대학원 의학과 석사 학위취득
1993. 02 부산대학교 대학원 의학과 박사 학위취득
1996-1997: Visiting Professor: University of Minnesota,
Stem Cell Therapy
Kim SJ, Cho HH, Kim YJ, Seo SY, Kim HN, Lee JB, Kim JH, Chung JS, Jung JS. Human adipose stromal cells expanded in human serum promote engraftment of human peripheral blood hematopoietic stem cells in NOD/SCID mice. Biochem Biophys Res Commun. 2005 Apr 1;329(1):25-31.
Seo MJ, Suh SY, Bae YC, Jung JS. Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. Biochem Biophys Res Commun. 2005 Mar 4;328(1):258-64.
Park BS, Song YS, Yee SB, Lee BG, Seo SY, Park YC, Kim JM, Kim HM, Yoo YH. Phospho-ser 15-p53 translocates into mitochondria and interacts with Bcl-2 and Bcl-xL in eugenol-induced apoptosis. Apoptosis. 2005 Jan;10(1):193-200
Lee YH, Han JY, Seo SY, Kim KH, Lee YA, Lee YS, Lee HS, Hur WJ, Han H, Kwon HC, Kim JS, Kim HJ. Stem cells expressing homing receptors could be expanded from cryopreserved and unselected cord blood. J Korean Med Sci. 2004 Oct;19(5):635-9.
Kwon HC, Kim SH, Kim JS, Han H, Roh MS, Han JY, Seo SY, Lee YH, Kim HJ. Establishment and characterization of an STI571-resistant human myelogenous leukemia cell line, SR-1. Cancer Genet Cytogenet. 2004 Oct 1;154(1):52-6.
Lee YH, Lee YA, Noh KT, Kim KH, Han JY, Seo SY, Kwon HC, Kim JS, Kim HJ. Homing-associated cell adhesion molecules and cell cycle status on the nucleated cells in the bone marrow, mobilized peripheral blood and cord blood. J Korean Med Sci. 2004 Aug;19(4):523-8.
Kim KW, Kim SH, Jang JH, Lee EY, Park SW, Um JH, Lee YJ, Lee CH, Yoon S, Seo SY, Jeong MH, Lee ST, Chung BS, Kang CD. Dendritic cells loaded with exogenous antigen by electroporation can enhance MHC class I-mediated antitumor immunity. Cancer Immunol Immunother. 2004 Apr;53(4):315-22. Epub 2003 Dec 18.
Choi HJ, Kim HH, Lee HS, Huh GY, Seo SY, Jeong JH, Kim JM, Yoo YH. Lactacystin augments the sulindac-induced apoptosis in HT-29 cells. Apoptosis. 2003 Jun;8(3):301-5.
Shin JY, Lee SK, Kang CD, Chung JS, Lee EY, Seo SY, Lee SY, Baek SY, Kim BS, Kim JB, Yoon S. Antitumor effect of intratumoral administration of dendritic cell combination with vincristine chemotherapy in a murine fibrosarcoma model. Histol Histopathol. 2003 Apr;18(2):435-47.
Seo SY, Jun EJ, Jung SM, Kim KH, Lim YJ, Park BS, Kim JK, Lee S, Suh H, Kim ND, Yoo YH. Synthetic chenodeoxycholic acid derivative HS-1200-induced apoptosis of p815 mastocytoma cells is augmented by co-treatment with lactacystin. Anticancer Drugs. 2003 Mar;14(3):219-25
Lee YH, Han JY, Seo SY, Kim KH, Lee YA, Lee HS, Hur WJ, Han H, Kwon HC, Kim JS, Kim HJ. Urokinase could increase the yield of progenitor cells during red cell depletion in elapsed and anticoagulated cord blood. Am J Hematol. 2002 Dec;71(4):336-9.
Park BS, Baek SJ, Song KH, Kim KH, Jeong SJ, Jeong MH, Seo SY, Lee SW, Yoo KS, Yoo YH. Genistein-induced apoptosis of p815 mastocytoma cells is mediated by Bax and augmented by a proteasome inhibitor, lactacystin. Nutr Cancer. 2002;42(2):248-55.
Lee HJ, Choi SS, Park MK, An YJ, Seo SY, Kim MC, Hong SH, Hwang TH, Kang DY, Garber AJ, Kim DK. Fenofibrate lowers abdominal and skeletal adiposity and improves insulin sensitivity in OLETF rats. Biochem Biophys Res Commun. 2002 Aug 16;296(2):293-9.
1987. 02 부산대학교 의과대학 졸업
동아대학교 의과대학 생리학교실
1989. 02 부산대학교 대학원 의학과 석사 학위취득
1992. 02 부산대학교 대학원 의학과 박사 학위취득
1988-1990: 미국 캘리포니아주립대학(UCSF, CVRI)
1997-1998: 미국 스탠퍼드대 세포분자생리학교실
Membrane trafficking 및 관련 질환
Kang DY, Park JI, Cho WS, Jeong MH, Cho GW, Park HT, Bae HR
Identification of vasopressin-induced genes in AQP2-transfected MDCK cells by suppression subtractive hybridization.
Biochemical and Biophysical Research Communications 324 (2004) 1234-1241
Cha JK, Jo WS, Shin HC, Bae HR, Ho JM, Kim JW.
Increased platelet CD63 and P-selectin expression persist in atherosclerotic ischemic stroke.
Platelets. 15(1):3-7 (2004).
Cha JK, Jeong MH, Jang JY, Bae HR, Lim YJ, Kim JS, Kim SH, Kim JW
Serial Measurement of Surface Expressions of CD63, P-Selectin and CD40 Ligand on Platelets in Atherosclerotic Ischemic Stroke. A Possible Role of CD40 Ligand on Platelets in Atherosclerotic Ischemic Stroke.
Cerebrovasc Dis. 16(4):376-82 (2003)
Lee SH, Kim SR, Kim JS, Bae HR, Lee CH, Kim DD,
In-vitro and in-vivo antibacterial activity evaluation of a polyurethane matrix.
J Pharm Pharmacol 55(4) 559-566 (2003)
Kim JM, Bae HR, Park BS, Lee JM, Ahn HB, Rho JH, Yoo KW, Park WC, Rho SH, Yoon HS, Yoo YH
Early mitochondrial hyperpolarization and intracellular alkalinization in lactacystin-induced apoptosis of retinal pigment epithelial cells.
J Pharmacol Exp Ther 305(2) 474-481 (2003)
Cha JK, Jeong MH, Lee KM, Bae HR, Lim YJ, Park KW, Cheon SM
Changes in platelet p-selectin and in plasma C-reactive protein in acute atherosclerotic ischemic stroke treated with a loading dose of clopidogrel.
J Thromb Thrombolysis 14(2) 140-150 (2002)
Lee SH, Jeong SJ, Jang JM, Jeong MH, Bae HR, Lim YJ, Kim SH, Kim JW, Cha JK
Circulating levels of IL-8 and VEGF in patients with Carotid Stenosis.
J. Kor. Med. Sci. 16(2), 198-203 (2001)
Huh GY, Roh MS, Bae HR,
Age-related regional difference of interleukin-1 expression in rat brain after lipopolysaccharide treatment.
J Kor. Med Sci 16(1):103-7 (2001)
Jeong SJ, Jin YH, Moon CW, Bae HR, Yoo YH, Lee HS, Jeong MH
Protein tyrosine kinase inhibitors modulate radiosensitivity and radiation-induced apoptosis in K562 cells
Radiation Research 156:751-760 (2001)
Park SJ, Cho SS, Oh JM, Han MK, Song YS, Bae HR, Yoo YH, Kim HM
Promoted expression of mast cell-specific proteases in IgE-dependent passive cutaneous anaphylaxis responses
Clinica Chimica Acta, 314:231-236 (2001)
동아대학교 의과대학 해부학교실
동아대학교 의과대학 미생학교실
1987. 02 부산대학교 의과대학 졸업
1989. 02 부산대학교 대학원 의학과 석사 학위취득
1991. 02 부산대학교 대학원 의학과 박사 학위취득
1. 면역 병리에 의한 병인과정
Jeong MH, Jo WS, Jin YH, Jang JY, Nam BH, Son SH, Choi SS, YOO YH, Kang CD, Lee JD, Joeng SJ,
Loss of mitochondrial membrane potential and caspase activation enhance apoptosis in irradiated K562 cells treated with herbimycin A.
International Journal of Radiation Biology, 2005, in press.
Cha JK, Jeong MH, kim JW.
Statin reduce the platelet P-selectin expression in atherosclerotic ischemic stroke.
J. Thromb. Thrombolysis 18(1):39-42, 2004.
Jeong MH, Jin YH, Kang EY, Jo WS, Park HT, Lee JD, Yoo YJ, Jeong SJ.
The modulation of radiation-induced cell death by genistein in K562 cells: Activation of thymidine kinase 1.
Cell Res 14(4):295-302, 2004.
Jeong SJ, Jin YH, Moon CW, Bae HR, Yoo YH, Lee HS, Lee SH, Lim YJ, Lee JD, Jeong MH.
Protein tyrosine kinase inhibitors modulate the radiosensitivity and radiation-induced apoptosis in K562 cells.
Radiation Research 156:751-761, 2001.
Jeong SJ, Yee ST, Jo WS, Yu SH, Lee SH, Lim YJ, Yoo YH, Kim JM, Lee JD, Jeong MH.
A Novel Factor isolated from Actinobacillus actinomycetemcomitans Stimulates Mouse B Cells and Human Peripheral Blood Mononuclear Cells.
Infect. Immun. 68(9):5132-5138 , 2000.
동아대학교 의과대학 병리학교실
1973. 02 부산대학교 의과대학 의학과 졸업
1981. 02 한양대학교 대학원 의학과 석사 학위취득
1985. 02 부산대학교 대학원 의학과 박사 학위취득
1988-1989: Visiting Professor (Pathology) Emory Univisity, Geogia, USA
Epithelioid angiosarcoma of the pleura : A case report
Mee Sook Roh, Ji Young Seo, Sook Hee Hong
Journal of Korean Medical Science 16(6) : 792-5, 2001
Left atrial myxosarcoma with systemic metastasis : A case report
Mee Sook Roh, Gi Yeoung Huh, Jin Sook Jeong, Gie Deug Lee, Sook Hee Hong
Journal of Korean Medical Science 16(1) : 111-114, 2001
Occurrence and prognotic implications of micrometastases in lymph nodes from patients with submucosal gastric carcinoma
Hong-Jo Choi, Yun-Ki Kim, Young-Hoon Kim, Sang-Soon Kim, Sook-Hee Hong
Annals of Surgical Oncology 9 (1), 13-19, 2002
Comparison of clinicopathologic characteristics and genetic alterations between microsatellite instablility-positive and microsatellite instability- negative sporadic colorectal carcinomas in patients younger than 40 years old
Jae Hee Suh, So-Dug Lim, Jin Cheon Kim, Sook Hee Hong, Gyeong Hoon Kang
Dis Colon Rectum 45 (2): 219-228, 2002
Incidence and Prognostic Implications of Isolated Tumor Cells in Lymph Nodes from Patients with Dukes B Colorectal Carcinoma
Hong-Jo Choi, Yun-Young Choi, Sook-Hee Hong
Dis Colon Rectum 45 (6): 750-756, 2002
Utility of Thyroid Transcription Factor-1 and Cytokeratin 20 in Identifying the Origin of Metastatic Carcinomas of Cervical Lymph Nodes
Mee Sook Roh, Sook Hee Hong
Journal of Korean Medical Science 17 (4) : 512-517, 2002
Fenofibrate lowers abdominal and skeletal adiposity and improves insulin sensitivity in OLETF rats
HJ Lee, SS Choi, MK Park, YJ An, SY Seo, MC Kim, SH Hong, TH Hwang, DY Kang, AJ Garber, DK Kim
Biochemical and Biophysical Research Communications 296: 293-299, 2002
Changes in expression of cell cycle regulators after G1 progression upon repetitive thioacetamide treatment in rat liver
Sook Hee Hong, Gie Deug Lee, Jun Young Chung, Kyung Sook Cho,
Seok Hee Park, In-Hoo Kim, Jin Sook Jeong
Experimental and molecular medicine 34 (5) : 361-366, 2002
Prevalence of human papillomavirus infection in women in Busan, South Korea
Hai-Rim Shin, Duk-Hee Lee, Rolando Herrero, Jennifer S. Smith, Salvatore Vaccarella, Sook-Hee Hong, Gap-Yeol Jung, Hyun-Ho Kim, Un-Dong Park, Hyung-Su Cha, Soyoon Park, Antoine Touze, Nubia Munoz, Peter J. F. Snuders, Chris J. L. M. Meuer,, Pierre Coursaget. Silvia Franceschi
Int J Cancer 103 (3) : 413-421, 2003
Gene Expression Profiling of Breast Cancers with Emphasis of β-Catenin Regulation
Mee Sook Roh, Sook Hee Hong, Jin Sook Jeong, Hyuk Chan Kwon, Min Chan Kim, Se Heon Cho, Jin Han Yoon, Tae Ho Hwang.
Journal of Korean Medical Science 19(2): 275-82, 2004
Utility of GLUT1 in the Differential Diagnosis of Liver Carcinomas Mee Sook Roh, Jin Sook Jeong, Young Hoon Kim, Min Chan Kim, Sook Hee Hong
Hepato-Gastroenterology 51: 1315-1318, 2004.